Results for: Science and Medicine


JENNER, EDWARD (1749-1823). English scientist who pioneered the development of vaccination by developing smallpox vaccine.
Autograph Manuscript Signed, 8vo, n.p., ca. 1822.
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To his son. “My dear Tetel, Even if I write you so little, I love you very dearly and often think how hard you must be cramming for your graduation. But that too will be over and you will be a free little man, as free as circumstances will allow, which will be a serious limitation in itself. I wonder when I will get to see you? The beautiful sailboat will be finished by the end of the week. But for now it will have to stay on Plesch’s estate, and I along with it. You will be able to relax and recover. I am doing quite well, much better than a few months ago. But I am not quite over it. The house is being built in Caputh now (nomen est omen) [Latin: “a fitting name”]. It is terribly expensive, and the city has made it so ugly that I refused their gift. I intend to move to Caputh fulltime, because the dual living arrangements would get too expensive. You will be charmed by the location. It should be finished by the end of September. Mama’s letter about the money from New York has not arrived yet; do remind her of it and give her my love. Write me a little note  sometime soon (no need for more in your current stress) and let me send you a kiss.”  Signed, “Your Papa!” He continues in a postscript. “I enjoyed my visit with Ada, and I have the impression that the two are living quite happily. The situation has turned out much less dire than I had feared a while back.”
EINSTEIN, ALBERT (1879-1955) German-born theoretical physicist who is best known for his theory of relativity and specifically mass-energy equivalence, E = mc2. He was awarded the 1921 Nobel Prize in Physics "for his services to Theoretical Physics, and especially for his discovery of the law of the photoelectric effect.”
Autograph Letter Signed, in German, 2 pages on one 4to sheet, June 5, 1929.
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BOYLE, ROBERT (1627-1691). Important Irish-born English scientist who was a natural philosopher, chemist, physicist, inventor, and gentleman scientist, also noted for his writings in theology. He is best known for the formulation of Boyle's law. Although his research and personal philosophy clearly has its roots in the alchemical tradition.
Autograph Letter Signed. two pages 4to, Oxford, November 11, 1665.”
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EINSTEIN, ALBERT (1879 1955). Einstein was a German born physicist, humanitarian, Nobel Prize winner and the founder of the General Theory of Relativity.
Typed Letter Signed, in English, 4to, Princeton. March 28, 1938.
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The letter is written to Danish editor, Ole Cavling. Bohr first thanks him for “the pamphlet Confluence, which I look forward to reading and which I afterwards will send on to my son.” Bohr continues, I send you…a copy of my unfortunately probably very heavily written article for the Columbia conference in the fall.” Signed, Niels Bohr".
BOHR, NIELS (1885-1962) Danish physicist who made fundamental contributions to understanding atomic structure and quantum mechanics, for which he received the Nobel Prize in Physics in 1922. He was also part of the team of physicists working on the Manhattan Project.
Typed Letter Signed, in Danish, 4to, Copenhagen, February 15, 1955. Also included is the rare 21 page carbon copy of the transcript to Bohr’s lecture, in English, “Science and the Unity of Knowledge” given October 28, 1954, at the conferenc
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Hoffmann, one of the most famous doctors of his time, writes this letter to Philipp Mueller, a provost in Magdeburg, who had just consulted with him. Hoffmann answers by summing up for Mueller in a few lines his essential ideas on the art of medicine. "Because moral philosophy is not foreign to me, I consider work in the natural sciences (medicine) as very connected to it. With humans everything that concerns the mind and the body may be reduced to what the doctor knows, and I do not think that any one else may know better the very essence and the functions of the mind than the person who has been immersed in the knowledge of natural things. The mind (head, thinking) is intimately linked to the strength of the body. So weather conditions and the nervous system may influence the mind differently and derange it. For this reason, a doctor must treat at the same time head and body functions, etc." Hoffmann then talks in detail about some medicinal plants (veronica, rosemary, sage) as well as about a therapy that he recommends to strengthen one's hand fingers by using a combination of "balm" (Peruvian balsam) and oil. He finally brings up his writing against the affirmations made by Bontekoe and the School of Chemists, on the subject of certain acid deficiencies in the body, thought to be the origin of all diseases. A superb early letter signed in Latin, "Excellentiss. Nominis Tui Cultor perpetuus Fr. Hoffmann." Letters of Hoffmann, the seventeenth century physician are rare.
HOFFMANN, FRIEDRICH. (1669-1742) German physician; experimented with various remedies. He was an influential theorist who systematized medicine.
Manuscript Letter Signed, in Latin, 4 pages, Halle, March 15, 1694.
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He writes to Hans Spemann, German embryologist and later winner of a Nobel Prize: "Hertwig has not finally made up his mind, and together we have drafted the enclosed call, which has been signed by several people (Göbel, Hertwig, Borst, Reichert, Wien, Leube, from you, the board of the zoological society and myself) and will be sent to a broader circle. May I count on your signature as well? With best wishes for the holidays and with friendly greetings," signed, "W.C. Röentgen."
ROENTGEN, WILHELM (1845-1923) German physicist, discoverer of X-rays, and winner of the first ever Nobel Prize in Physics (1901).
A.L.S., in German, 1 p, watermarked 8vo, Weilheim, Germany, Dec. 24, 1916.
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He writes a lengthy letter: "Idiocy that, if in the story used here it is literally not equivocal, is only a few months old and was produced for no obvious reason, should be surmountable in some way by [medical] skill. I say should be because if the young man has never given any sign of mental weakness whatsoever in his childhood, you have to worry that the illness is congenital and that it developed little by little to the current condition and that perhaps it increases even more when, with the beginning of puberty and of the preparation of prolific in the designated organs, no beneficial change occurs. In similar cases [medical] skill has no more effective treatments than those of elimination and bloodletting; and those are administered by surgery or medication. Surgery suggest first of all the opening of the hemorrhoidal veins by way of leeches. Submerged in a cold bath or shower with constant dripping on the crown of the head. And finally cauterizing in the nape of the neck. If it turns out that those treatments have to be used over a long time, a skilled person should perform them. As far as pharmaceutical remedies are concerned, it is probably difficult to make the young patient swallow medication. You may be able to trick him pretending to be making coffee while preparing oriental senna, or with another method. Or finally, by having a solution of hellebor prepared to be taken a few times in the discussed quantity, with which the common can be swallowed. If the practice of these remedies shows improvement from June to autumn, the writer suggests bone grafting. This result would probably have to be a long time and be maintained until healing, with the warning not to reverse it with reactions."
CALDANI , LEOPOLDDO MARCO ANTONIO (1725 - 1813) Italian anatomist and physiologist. He is noted for his experimental studies on the function of the spinal cord and for the introduction of electricity in the physiology of the nerves. His most celebrated work is his anatomical atlas made in collaboration with his nephew.
Excellent Autograph Letter Signed, in Italian, 4to, Padua, April 12, 1789.
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SABIN, ALBERT (1906-93) Russian born, American medical researcher who is best known for having developed the widely successful oral vaccine for polio.
Autograph Manuscript Signed, in pencil, titled, “Science and the Future Direction of Humanity,” 12 lined 4to pages, George Washington University, February 12, 1986.
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Mercuri writes, “The person delivering the letter is a friend of mine and an exiled patriot of the Church State and of Padua, which [used to pay] for his service, but I am asking you to assume the burden for 8 - 10 days….”  Handwritten address on the back. “To Gio. Battista Pico Secr.y of  the S.A.” of Parma.
MERCURI, SCIPIONE GIROLAMO (1540-1615) Roman medical physician, scientist, and author of what can be considered the first Italian treatise on obstetrics from the sixteenth century. The book, La comare o raccoglitrice (1596) which contains the first indications for the execution of cesarean sections.
Beautiful Autograph Letter Signed, in Italian, oblong 8vo, n.d.
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Sommerfeld answers three questions: “1. Were your scientific ‘debuts’ easy or difficult? 2. Did means of living …enable you to make yourself known in science? 3. What work…made yourself more famous? Which do you consider your masterpiece?”  In reply, Sommerfeld answers:  “1) Being a doctor’s son in Königsberg I had no difficulty studying at the university there and completing my general education.  2) Positions as assistant in Göttingen, (first at the Institute of Mineralogy with Th. Liebisch, then at the Institute of Mathematics with F. Klein) and a stipend for an associate professorship allowed me the  necessary peace of mind to continue my work on mathematical physics. 3) Scientific papers about Maxwell’s equations and a book (co-authored with F. Klein) about gyro theory were met with general recognition. I became tenured professor at age 29. My most important papers are about the completion of Bohr’s nuclear model, the ‘spectalline’ theory, specifically their structure,  and quantum theory of  the electrons of metals….”  Signed, “A. Sommerfeld.”
SOMMERFELD,.ARNOLD (1868-1951). German theoretical physicist who pioneered developments in atomic and quantum physics, and also educated and groomed a large number of students for the new era of theoretical physics. He introduced the fine-structure constant into quantum mechanics.
Autograph Document Signed, in German, 4to, Munich, September 28, 1950.
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To his Son-in-Law, ”There couldn’t be more reassuring news than what you gave me. Oh, what beautiful horns have grown on your enemies! They are so long that they stretch from Padua to Tavia. I can only hope that a similar extension will grow all the way from their buttocks to their throat and suffocate them just as they deserve. The recent news from here is that the magistrate has not agreed on the desired stipend that was not considerable…. So while I have taken on your cause, I am writing a forceful letter to a powerful patrician my son-in-law to move the disposition of His Excellency Gabrieli, the actual state inquirer, so that he then will speak forcefully to E. Bembo who wants to do everything to please His Exc. Gabrieli. Please remind His E. Vindmorin of the public letter so that you can collect (just like others, and, as was done with others, it did not happen barbarically to me) the usual anticipated sum, namely 24 ducats. A letter like that needs to be issued to you with the aid of the Senate. I imagine you have given yourself pleasant recourse at the house that is more or less yours, that is with my most beloved daughter. I hope and pray that such news did not overwhelm her sensibility too forcefully. More immediately, even though it has happened to you, no professor has ever been elected, and this is good. I gave the two ducats back to the noted Domenican friar as a gift. If you ever find yourself short, know that you must not think about the [table / food]. There is a spot here in my philosopher’s refectory, that is, there is enough here to sustain life. As far as sleeping goes, there is room in the house of my servant just a few steps across from me. My bed is really large, but I don’t want to sleep with you. Having been far from your house for several weeks, I don’t want to compensate and be too close now. Adieu, dear friend, let’s show the rascals for what they are; one of these days they are bound to come to a bad end.” Signed, “Adieu again, Your Caldani” In a postscript, Caldani continues, “If you have opportunity to see the generous and estimable Sig. Sanferno, greet him in my name and remind him of my affairs so that we may be given what has been withheld from me and given to other people.”
CALDANI , LEOPOLDO MARCO ANTONIO 1725–1813) Italian anatomist and physiologist. He is noted for his experimental studies on the function of the spinal cord and for the introduction of electricity in the physiology of the nerves. His most celebrated work is his anatomical atlas made in collaboration with his nephew.
Autograph Letter Signed, in Italian, two 4to pages, Padua, March 9, 1794.
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To G.P. Lowery. “Have read Mr. White’s letter with the other correspondence relating to Manchester affairs. I approve of the concession proposed by Mr. Bouverie”. Signed, with his early magnificent umbrella signature, “Yours Thomas A. Edison”
EDISON, THOMAS ALVA (1847-1931) American inventor. Among his many inventions, of which he patented over a thousand, were an automatic telegraph repeater, printing telegraph, electric pen, the photograph and the incandescent lamp.
Rare Early Autograph Letter Signed, oblong 8vo, New York, February 9, 1883.
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Bohr poignantly writes, “Contrasts are not contradictory but complimentary.”  Boldly signed, “Niels Bohr.”
BOHR, NIELS (1885-1962). Danish physicist who received the Nobel Prize for Physics in1922. He is the main contributor to the understanding of the structure of the atom as well as to the development of quantum mechanics.
Rare Autograph Quotation Signed, in English, small oblong 8vo, Paris, December 20, 1951.
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Ornately printed in the center of this ornate document is the following, “The Philomathic Society of Paris, during its session of April 30, 1808, welcomed, as one of its correspondents, Mr. Girard, Professor at the Imperial Veterinary School at Alfort.” Signed on the lower half of this document, “Aquebert-Montbret, President” and below the President, “A. Ampère, Secretary.”
AMPERE, ANDRE-MARIE (1775-1836). French physicist and mathematician who is generally credited as one of the main discoverers of electromagnetism. The SI unit of measurement of electric current, the ampere, is named after him.
Magnificent Manuscript and Printed Document Signed, oblong folio, with attractive borders and red wax seal, Paris, during its session of April 30, 1808.
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SABIN, ALBERT (1906-93). American physician and medical researcher. Created effective vaccines while working with the Army Medical Corps during World War II. +
A.M.S., thirteen numbered 4to pages with one additional page of additions, n.p., 1980.
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Dr. Sabin, now 80 years old, is sending a manuscript as a gift. ". Because of your moving 'bitte, bitte' appeal I tried very hard to find some pages of original manuscript that I am sending you herewith." He signs the letter "Albert B. Sabin," in his capacity as Senior Expert Consultant of the Fogarty International Center. The 1986 lecture is interesting, one he prepared for the Twenty-third Cosmos Club Award Lecture at the Cosmos Club in Washington, DC. He titles it "Role of My Cooperation with Soviet Scientists in the Conquest of Polio: Some Lessons and Challenges". "So you will not be thinking of polio in the abstract - as an ancient crippling and occasionally fatal disease - let me quickly show a few slides of children with the miserable residues of this disease. Some people think that this crippling disease which has been part of the human heritage since earliest evolutionary times has already been conquered, i.e. eliminated, brought under control, or even eradicated." It is mostly true for the cooler countries having less than half the world's population, where "during the last 20 years the oral polio vaccine has prevented about five million cases of persistent paralysis and perhaps 500,000 deaths. But it is not true for most tropical and sub-tropical, economically underdeveloped countries inhabited by about 2,500 million people . where crippling polio remains a serious public health problem with an estimated average of 250,000 -400,000 new paralytic cases per year" and uncounted deaths, particularly in Asia and Africa. Persistent paralytic polio is caused primarily by any of three viruses; it is these three that Sabin's vaccines prevent. The Sabin oral vaccines use live virus, which lives in the patient's gut as a benign infection and stimulates production of antibodies which also kill the three terrible versions of polio. Once vaccinated a person excretes live virus and actually passes the benign infection to others, a kind of passive vaccination. Reported polio infection in the U.S. has dropped from 13,500 per 100 million before 1955 to 4 per 100 million in 1985. But there are additional viruses which cause polio and for which there is no vaccine, says Sabin. "Even people who should know better seem to forget that in the prevaccine era - a little over 30 years ago - it was estimated that perhaps as much as 1% of all . cases in the USA was caused by other viruses . against which it is impractical to prepare vaccines." They accounted for nearly 32,500 polio cases per year in the U.S. alone, and statistically 325 of those should still result in persistent paralysis. "And yet during the last 11 years, excluding a few imported cases, the yearly average of [reported cases] has been about 7. What has happened to all the paralytic polio cases caused by other viruses that we used to have in this country 25 to 35 years ago?" The implication is that the industrial world's medical guard may be down and polio may be going undiagnosed in places like the U.S. and Europe. Since he has always known that polio is still rampant in Third World countries, he knows that the danger is still there. Written in pencil, with holograph corrections in pencil and pen. He has written "Albert B. Sabin" on the title page of the lecture.
SABIN, ALBERT (1906-93) American physician and medical researcher. Created effective vaccines while working with the Army Medical Corps during World War II. Released his attenuated-virus polio vaccine for use by other researchers. Created an oral v
Typed Letter Signed on "Public Health Service National Institutes of Health" stationery 4to, Bethesda, MD, June 6, 1986, and Autograph Manuscript Signed, 15 pages 4to, for a lecture in Washington, DC on April 15, 1986.
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Louis confirms the receipt of Portal's report and promises it will be read soon before the Academy of Surgery. "I think I will answer your trust, telling you, naturally, I doubt this report will be favorable to you. I see, from your essay that you do not know the historical and critical argumentation I added at the beginning of the last printing of Mr. Petit's bones diseases treatise, which I was the editor of. I studied, between him and his opponents, in a contradictory way, the part about his machine for dislocation. I didn't hesitate to tell what I was thinking about it and I believe it is worth nothing. I stated a few principles, rather vague to tell the truth, about dislocation surgery ; his germs gave birth to new methods and MM. Dupoy and Fabre, members of the Academy, gave some very interesting information about the manner of operating in a more simple way and more usefully than with machines, to reduce dislocations. By becoming more simple, surgery is getting more learned, as it is simplified by better thinking about different ways and links between causes and effects, what leads to real Philosophy, cognito rerum percausas...." Louis then criticizes the politics of the academy as it encourages research on machines that often appear ineffectual when they are used. It is the reason he shows so little enthusiasm for Portal's machine. He invites him to be self-contented with the approval of Société Royale des Sciences de Montpellier. Then continues, "This machine is more than what you need to give as an approval that would be for the public the guarantee of your genius. The approval of the Academy of Surgery cannot be absolute. If the academy believes your machine useful, it could only pronounce it in relation to the knowing it has of other measures or other rather similar, or accentuate the same intentions. And then Mr., you would not have the absolute satisfaction that you sure must desire...." He signs.  "Louis".
LOUIS, DR. P.C. ANTOINE (1723-92) French medical doctor. Shortly before his death, with Joseph Ignace Guillotin (1738-1814), he began construction of the executing machine that now bears the name of his co-inventor.
Autograph Letter Signed, in French, two pages with integral address page, 4to, Paris, June 10, 1764.
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